【Package Specifications】

50 tests/kit, 100 tests/kit, 200 tests/kit, 400 tests/kit

Quality Controls for CRP: 3 levels（optional）

Quality Controls for SAA: 3 levels（optional）

【Intended Use】

C Reactive Protein and Serum Amyloid A Assay Kit is used for the quantitative detection of C reactive protein and serum amyloid a in human whole blood, serum, or plasma specimens in vitro.

【Summary】

C-reactive protein (CRP) is an acute phase response protein whose concentration rises non-specially in response to the inflammation.  CRP is seen to increase as a result of the inflammatory process, most notably in response to pneumococcal (bacterial) infection, histolytic disease, and a variety of other disease states. CRP has been used as a sensitive indicator of infection and inflammation, in addition to monitoring the response of patients after surgery and providing the early diagnosis of infant infection. The state of constantly high level of CRP within the normal range (less than 10 µg/mL) is an indicator which is associated with mortality from cardiomyopathy. It can be used as an independent risk factor for cardiovascular disease. Serum Amyloid A (SAA) is an acute phase response protein whose concentration rises non-specially in response to the inflammation.  SAA is observed to increase as a result of the inflammatory process, most notably in response to bacterial or viral infection, tissue injury, and a variety of other disease state. SAA has been used as a sensitive indicator of infection and inflammation. SAA level in human serum could increase up to 1000 folds during infection and decrease rapidly after cured.

【Assay Principle 】

When an antigen-antibody reaction occurs between CRP or SAA in a sample and anti-CRP or anti-SAA antibody, which has been linked to latex particles, agglutination results. This agglutination is detected as a change of intensity of light scattering from the agglutinates, with the changing rate being proportional to the concentration of CRP or SAA in the sample. Based on the calibration curve loaded on the calibration card, CRP or SAA concentration in the sample can be determined